Pharmaceutical companies are shifting the clinical examinations of new pharmaceuticals outside of Slovakia, what may threaten seriously ill patients. This was caused by the amendment to the act on pharmaceuticals approved at the end of last year. According to it the submitter of clinical examination has to pay not only the costs related to study, like it is in other European countries, but also the costs associated with the treatment of patient during the clinical examination. Threat of clinical examination in Slovakia was also recognized by State Institute for Control of Pharmaceuticals.